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Half of the down-regulated mitochondrial genes have been described to be regulated by RELA.
Both of these processes have been described to be regulated by Vegfc during zebrafish embryonic development.
The MICA/B expression has been described to be regulated by the transcription factor heat shock factor 1 (HSF1).
TRPM2 channel opening was described to be regulated by ADPR, with cADPR also playing a crucial role as co-activator [ 28, 29].
Six of the twelve ortholog genes have previously been described to be regulated by estrogen while the remaining genes have yet to be independently verified as estrogen-responsive.
The effects of glucocorticoids on SP-D production have been previously described to be regulated at the level of transcription in in vitro studies (17).
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Importantly, we discovered ten novel, p53-inducible targets regulated in an NGF-responsive manner, including the sesn3 and nme1 targets recently described to be p53 regulated either by association or indirect experimental evidence [ 51, 52].
Some of the genes identified as hypermethylated by the arrays have already been described to be epigenetically regulated in ALL [10], [19], [20], [21], [22].
In conclusion the expression of the oncogenes NRAS, KRAS, and HRAS was described to be negatively regulated by several members of the let-7 family [ 42, 162].
For comparison also the expression of the genes in the set described to be up regulated under UPR conditions IRE1 and HAC1 dependently by [ 2] is included.
Serine 259 phosphorylation of RAF-1 that has been described to be negatively regulated by AKT phosphorylation remained unaffected in HT1197 and VmCUB1 cells but showed an increase in 253J cells (Zimmermann, 1999).
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