Exact(3)
N-terminal truncations of VDACs have previously been described to be functional in lipid-bilayer gating experiments but show altered voltage-dependence and decreased initiation of cell death.
In fact, some shed fragments have been described to be functional soluble receptors or ligands, which participate in autocrine, juxtacrine and paracrine signalling, or act as decoy receptors that sequester ligands to permit permanent signalling [ 56].
Interestingly, high quality matrices from TRANSFAC (minimizing false positives) did not detect any κB sites in the human promoter, and only detected one in mouse (at -998 bp, described to be functional) and one in rat (at -2.46 kb), which has never been described in the literature.
Similar(57)
Two Vκ genes (IGKV1-NL1 and IGKV3-NL5) found in the unselected library were described to be only potentially functional [ 48].
This mutation is predicted to produce an inframe deletion of 132 amino acids that disrupts the BRCT-N domain (p.Glu1559_Thr1691del) and it has been described to be deleterious by functional analysis [ 23].
The predicted proteome of the ISA1307 strain and of the type strain Z. bailii CLIB213T, whose ability to undergo meiosis is, as far as we know, unknown, was searched for proteins homologous to those described to be required for functional meiosis and mating in S. cerevisiae (Supplementary Table S7).
Ae2-GFP (in pXT7 vector, NCBI Reference Sequence: NM_009207.2) was previously described and shown to be functional [40].
All vectors described here were shown to be functional (see below).
The GFP-SR45 construct was described earlier and was shown to be functional [20].
In addition to the ring systems so far discussed, other rings have also been described as being functional in plastid division, and indeed observation of them far pre-dates those revealed by modern molecular genetics approaches.
Psychological symptoms frequently accompany severe injuries of the upper extremities and are described to influence functional outcome.
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