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Although early studies of the behavior of Prnp knockout mice described only minor changes [5], later studies reported that these mice develop an age-dependent impairment in memory consolidation, altered behavior and neurotransmission (see [6], [7] for reviews).
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However, these described only three minor incidents Reality Check had not already recorded, which have been included in the final tally.
However, we find this unlikely for two reasons: first, previous reports of gli2a gli2b double morphants described only relatively minor phenotypic effects of the knockdown of both proteins; and second, our demonstration that gli1 gli2a double mutants exhibit a strong loss of Hh response, which implies that Gli2b is unable to compensate for loss of Gli2a.
They had what sources described as only minor juvenile records.
The crystal structures described here manifest only minor conformational changes in the P-site loop region as a result of single or double mutation (Fig. 4).
In situ hybridization was performed on cryostat sections (20 µM) of specimens from HH24 embryos essentially as described previously with only minor modifications [13].
Lectin microarray analysis was performed as described previously, with only minor modifications [ 30].
The methods described above need only minor adaption for the setting of linear regression of Y on X, Z and XZ.
Using partial purified enzyme as described in this paper, only minor amounts of monosaccharides (3% galactose, 2.5% glucose) could be detected and therefore the obtained purity is sufficient for the intended use of CDH.
We show that earthslides in pelitic flysch formations accelerate faster than earthflows in chaotic clay shales and reach higher velocities, while the kinematic behaviour of the earthflows can be described as rather steady with only minor accelerations.
These organisms entirely lack the genes required for de novo purine biosynthesis enzymes, with only minor exceptions, described below.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com