Exact(6)
All three alleles fail to complement each other or Tsc2 192.1, a previously described null allele.
To expand on these RNAi studies we have also analyzed a previously described null mutant Rack1[1.8].
The qm mutations are indeed responsible for the oocyte phenotypes because germline clones of the previously described null allele (Lai et al. 1998) have the same maternal phenotype.
The overgrowth of unc-104 bris/− NMJs was unexpected because previously described null and hypomorphic alleles cause defects in bouton formation and decreased number of boutons per NMJ, respectively (Pack-Chung et al. 2007; Barkus et al. 2008).
We confirmed that the nudE nonsense mutation explains the 11R2 phenotype by showing that germline clones of nudE 39A, a previously described null allele (Wainman et al. 2009), also fail to specify an oocyte.
The lack of DRG defects in the ingls mice, in contrast to the previously described null mutants, suggests that VAC14 could have an important function in human neurological disorders that are restricted to the CNS and have not yet been tested.
Similar(54)
Parkin-null animals harbored the previously described park null allele (Greene et al., 2003), and were composed of the genotype CyO/IF; park /park.
Two control mutants that are described as null alleles in humans, R616P and R616W, did not rescue the lethal xpd-null phenotype in Drosophila, whereas most of the other mutant xpd alleles did.
Electromagnetic radiation is described by null geodesics of the background spacetime (in this case Kerr), and these are calculated in BHOSS using a Runge-Kutta-Fehlberg integrator with fourth order adaptive step sizing and 5th order error control.
Previously described gurken null alleles are not complete deletions and produce significant amounts of gurken transcripts (unpublished observations).
One of them was an agonist (1I7U) of the TCR and the others were described as null (1I7T) and antagonist peptides (1I7R).
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