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F4TERC−/− and F4TERC−/−CDKN1A−/− mice were generated as described, maintained on a C57Bl/6J background (Choudhury et al., 2007) and used at around 1 year of age.

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The mutant mice used in this study carried the sirt1-null allele previously described [11] maintained on a mixed genetic background derived from intercrosses between the CD1 out bred strain and 129/J.

CypA−/− mice were generated as described and maintained on a mixed genetic background.

Pvalb-Cre transgenic (PV-Cre-TG) mice express Cre in the majority of PV cells were previously described (42), and maintained on a C57BL/6J background.

C57BL/6 mice were from CLEA Japan Inc. Clec7a (Dectin-1) −/−, Irf3 −/−, Irf5 −/−, Irf7 −/−, Rag1 −/−, and Myd88 −/− mice as described previously were maintained on a C57BL/6 genetic background (Sato et al., 2000; Honda et al., 2005; Takaoka et al., 2005; Honda and Taniguchi, 2006; Saijo et al., 2007; Kano et al., 2008).

Retinoblastoma-floxed (Rbfl) mice were described previously and maintained on an FVB/129 background.

The Ink4bKO mice used in this study were previously described and were maintained on an 129/Sv background.

pTre2-miR-203/Krt14-rtTA mice were generated as described previously and maintained on an FVB background (Jackson et al., 2013).

GFPu mice were generated as previously described [32] and maintained on a C57BL/6J background (Harlan Olac, Bichester, UK).

The Ndufs4 fky/fky mouse was generated by the spontaneous insertion of the B2 SINE (Short Interspersed Nuclear Element) into the NADH dehydrogenase (ubiquinone) Fe S protein 4 (Ndufs4) gene as previously described [ 12], and maintained on a BALB/c background.

Yap flox/flox mice have been described previously 21 and were maintained on a C57Bl/6J background.

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