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Notably, neither locus contained IS1151 or IS1470-related sequences, in contrast to previously described loci containing cpe, etx, iap/ibp and cpb [14], [15], [17], [49].
Four previously described loci associated in Caucasian studies were identified, 17q21, IL1RL1, IL33 and TSLP [ 56].
Of the 16 described loci, 12 were found to be polymorphic.
Local rearrangements might then have driven the evolution of new resistance specificities in the described loci.
So, some argue it is inevitable that the relative risk for newly described loci will trend consistently downward (Goldstein 2009).
This, however, did not always result in more pronounced linkage findings at previously described loci, but more often in diminished LOD scores.
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The strategy allowed us to restrict the previously described locus from 3.56 Mb to 0.22 Mb.
Previously described locus specific long-range PCR primers (Additional file 3) were used to amplify HLA-A, B, and C genes consisting of 5466, 4609, and 4802 base pairs, respectively [ 9].
From this perspective, it would be of considerable interest to see whether there are additive or interactive effects of CNTNAP2 with genetic variants affecting social cognition, such as a recently described locus on chromosome 5p14 (St Pourcain et al. 2010).
In this review, we describe the key loci that have been associated with SLE to date.
Although in all strains the T4SS conforms to the previously described split loci for vir genes, there is great diversity within these loci among strains.
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