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In the Times, A. M. Rosenthal, the paper's former executive editor, praised the U.N. meeting and described harm reduction as nothing more than the first step on the slippery slope to legalization.
Over three-quarters of reports described harm to patients.
Most reports (n = 463, 77%) described harm occurring to patients, with 381 (64%) experiencing low harm and 82 (14%) moderate harm or worse (see examples 1 and 2 in Box 1).
This view was held by all three consumer advocates and one researcher, who described harm in terms of minor physical discomfort and inconvenience, and denied that overdiagnosis or false positives caused harm: Women aren't being harmed by breast screening and society isn't being harmed by breast screening.
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The main domain interactions he described harming his mental health were 1) paid work-community interactions (being prevented from participating in recreational activities) and 2) high workload mixed with feeling he was not valued by his employer (reflected in the lack of overtime pay for weekend work) affecting his mental health while at home.
Besides adverse events, there are the ethical principles of beneficence and to do no harm which are relevant for describing harm.
First, key studies of irinotecan-based regimens consist primarily of Phase III clinical trials that cannot be identified by search terms that describe harm from medicines such as 'adverse reactions' and 'neutropaenia or diarrhoea'.
Second, attempts to identify studies other than Phase III trials that report the frequency of irinotecan adverse events yielded too many irrelevant publications but also missed key studies because (i) of the many terms to describe harm from medicines and (ii) these studies may not have these terms indexed as keywords.
Recent guidelines advise "terms that do not imply causality (such as 'adverse events') should be the default term to describe harms, unless causality is reasonably certain" [ 82].
A weighted-random sample of 12 500 incidents describing no harm, low harm and moderate harm of patients, and all incidents describing severe harm and death of patients will be classified.
Fifty-four per cent (n = 81) of these 151 incidents described patient harm, including 9% (n = 13) classified as moderate harm or worse.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com