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All the described compounds display unique molecular architectures, which have been determined by X-ray measurements.
The described compounds are derivatives of ether, carbamate, urea, amide, or amine.
Our current goal is to investigate the importance of the peptide sequence in determining overall biological properties of the previously described compounds.
In the present study, [68Ga]3 exhibited the lowest kidney uptake compared to the previously described compounds [68Ga]Ga-NODAGA-c RGDfK) and [68Ga]Ga-NODAGA-c RGDfK
For that reason, the described compounds in this manuscript should be well suited for a targeted 177Lu therapy to osteoblastic bone metastases, where they should preferably accumulate.
Its efficacy might however not solely depend on binding to CAIX, since all described compounds generally display low activity as carbonic anhydrase inhibitors.
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ALBERT EINSTEIN IS said to have described compound interest as the eighth wonder of the world.
Besides the already described compound serinol (2-amino-1,3-propanediol), several chiral derivatives exist.
The previously described compound vibralactone B (7) possessing an epoxy ring at C2 C3 was re-encountered in this research with a yield of more than 3 g [6].
The vibrational studies seem to be helpful in understanding of physical and chemical properties of described compound and also in design of new complexes with exactly defined behaviors.
Previously described compound heterozygous WFS1 mutations (p.Lys193Gln and p.Arg456His) were identified in one family (Cryns et al., 2003).
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