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ALBERT EINSTEIN IS said to have described compound interest as the eighth wonder of the world.
Besides the already described compound serinol (2-amino-1,3-propanediol), several chiral derivatives exist.
The vibrational studies seem to be helpful in understanding of physical and chemical properties of described compound and also in design of new complexes with exactly defined behaviors.
The previously described compound vibralactone B (7) possessing an epoxy ring at C2 C3 was re-encountered in this research with a yield of more than 3 g [6].
The crystal structures of four p-phenyl-substituted cis-9,10-diphenyl-9,10-dihydroanthracene-9,10-diols, carrying chloro- (1), bromo- (2), iodo- (3) and methyl substituents (4), respectively (with 2 being a previously described compound), have been studied in order to compare the effects of these substituents on the crystalline architecture.
As a first attempt, we used a recently described compound belonging to the family of pyrazones, namely UBE1-41, that can affect the initial step of the ubiquitination process by the covalent modification of the active site Cys of the Ub-activating enzyme E1 [32].
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All the described compounds display unique molecular architectures, which have been determined by X-ray measurements.
The described compounds are derivatives of ether, carbamate, urea, amide, or amine.
In the present study, [68Ga]3 exhibited the lowest kidney uptake compared to the previously described compounds [68Ga]Ga-NODAGA-c RGDfK) and [68Ga]Ga-NODAGA-c RGDfK
Our current goal is to investigate the importance of the peptide sequence in determining overall biological properties of the previously described compounds.
For that reason, the described compounds in this manuscript should be well suited for a targeted 177Lu therapy to osteoblastic bone metastases, where they should preferably accumulate.
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