Among the genes coding for transcriptional regulators, we identified three genes (BR1187, BR1378 and BR0872) belonging to the MerR, AspB, and ExoR family, respectively, as being down-regulated, the latter being described as repressing exopolysaccharide production.
It has been described as inducing and repressing a number of signaling pathways that control macrophage activation [ 35].
However, the C-terminus of large t -antigen, which was described as essential for repressing the function of p53 in HAdV-A12 infected cells, showed a high sequence homology to HAdV-A12.
In their paper, Cantone et al. describe GAL80 as repressing GAL4, but this is via their natural protein interaction properties.
The use of chromoproteins as reporter output is briefly mentioned, and small regulatory RNAs (sRNAs) described as a way to repress gene expression.
Sar homologues such as SarT and Rot are also described to repress transcription of hla [51], [52], [53], [54], [55].
In tomato, ARF4 was described to repress the expression of auxin-responsive genes, playing a key role in the control of sugar metabolism during fruit development, through the regulation of photosynthetic activity as well as chlorophyll and starch accumulation [ 103].
RELA has been described to repress BCL6 expression through interferon regulatory factor 4 [ 55].
Recently, microRNA, which are 21 23 nucleotide non-coding RNA, were described as post-transcriptional regulators of gene expression through repressing many specific target mRNA (Ambros, 2004).
Interestingly, cisplatin has been recently described as an ARF mimic in OS therapy as it represses signaling through the NFκB pathway via the same mechanism as ARF [46].
