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Remark 5 The method of the proof of Lemma 8 is referred to as the descending method in [6, 7, 13, 23 27], but the details in this paper are different.
Multivariate analyses were performed using a stepwise, descending method for factors with significance on univariate analyses.
A classical descending method was applied to select prognostic factors in each model (without frailties).
Explanatory variables with a p value < 0.25 were included in the multivariable model using a stepwise descending method (backward).
> -wrap-foot> In the absence of a caliper, the descending method provides the best matches, particularly when there is a large separation between exposed and unexposed subjects.
The best-first method gives the closest matches, and the ascending method may perform better than the descending method, depending on the separation between exposed and unexposed subjects.
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This method is referred to as the "ascending" method, and both ascending and descending methods are widely implemented.
With a tight caliper, there is little difference between the methods in terms of closeness of matches, although the best-first, random, and 5-to-1-digit methods are generally slightly better than the ascending and descending methods.
Chromosome conformation capture (3C) and descended methods (e.g. circular 3C, 4C; enhanced 4C, e4C; and Hi-C), as well as chromatin interaction paired-end tagging (ChIA-PET) techniques, examine long-range physical interactions between distal gene regulatory elements and promoter regions of target genes and have already been successfully applied to non-coding GWAS signals 11, 55, 56.
Note that 'LM, 'H', 'LM', and 'DS' stand for the Zhou method[4], the Huang method[11], the Lagrange multiplier method, and the descending search method, respectively.
We also describe a new algorithm for the descending storage method (DSM) based on a sort technique that makes creation of contact candidate pair lists more efficient.
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