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The distribution of DES in the IFM data shows a large variation of DES across genes: 58% genes have low dosage effect (DES < 0.2, Figure 3B), 37% have medium dosage effect (DES between 0.2 and 0.4), and only 5.2% (611 genes) have high dosage effect (DES > 0.4).
Although it took some time to uncover the cause and effect relationship, it was shown that if a woman took DES between the fifth and 18th weeks of pregnancy, her female offspring were at significant risk of developing the cancer.
In sharp contrast with this, both children and adults demonstrated significant EEG DEs between 140 320 ms after stimulus presentation.
Developmental exposure to DES between 9 and 16 days of gestation was shown to increase both trabecular and cortical femoral bone mass in female offspring [ 10].
Specifically, female offspring of rat dams exposed to a total of 1.2 μg DES either on gestation week 2 or 3 [ 16], to 0.6 μg or 4 μg DES on both gestation days 15 and 18 (all via injection) [ 18, 19], or via diet to 0.1, 1 or 10 ppm DES between gestation days 13 and 21 (week 3) [ 21] exhibited increased mammary cancer risk.
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Table 4 lists GO-terms overrepresented among transcripts identified as DE between RJ and WL.
The Euclidean distance (dE) between two expression profiles is defined as (2) with notations as for Equation (1).
Subsequently, we made two types of changes in the selected transcripts to create DE between two groups.
Wnt inhibitory factor 1 (was1) was identified as DE between females of the two strains, with WL having higher levels than RJ.
The phosphorochloridates 438 were obtained in 59 93% yields and diastereomeric excess (de) between 28%and87%7% depending on the nature of the aromatic moiety.
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