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Our study measured dermal uptake of pesticides of varying hydrophobicity (logKow) in frogs.
So far, no guidelines exist to investigate dermal uptake of chemicals across amphibian skin.
Liver toxicity was also described in rats after inhalation and dermal uptake of PFCs.
Currently, different physico-chemical properties are discussed to be possible predictors for the dermal uptake of a substance in amphibians.
The basic aim of this work was the adaption of a method to investigate the dermal uptake of chemicals in amphibians.
Within human risk assessment, dermal in vitro methods are already established and routinely used to assess the dermal uptake of test compounds after topical application.
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The older the participant, the higher were the dermal uptakes of both DEP and DnBP from air.
Dermal uptake, on the other hand, plays a secondary role, in spite of the fact that deodorants containing aluminum have been repeatedly suggested to be related to an increase in risk of breast cancer [8 10].
However, the ratios of dermal uptake to inhalation intake for DEP and DnBP assumed in the modeling studies of Bekö et al. (2013) and Gaspar et al. (2014) are higher than those measured in the current study.
The ratio of dermal uptake to inhalation intake predicted by Weschler and Nazaroff (2012, 2014) are based on a steady-state model.
This is significant because if metabolism occurs in the viable epidermis but not the stratum corneum, it will have a larger impact on the overall rate of dermal uptake for DEHP than for DEP and DnBP.
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