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There was no papillary dermal thickening.
Subcutaneous edema may also elevate the modified Rodnan skin score (MRSS), as edema can be difficult to distinguish from dermal thickening.
The 5-HT2 inhibitergurideuride and cyproheptadine as well as the selective 5-HT2B inhibitor SB 204741 [ 17- 20] efficiently prevented bleomycine-induced dermal thickening.
In the bleomycin-induced dermal fibrosis mouse model, CC-930 treatment dose-dependently reduced dermal thickening by up to 45%%, prevented the accumulation of collagen as measured by hydroxyproline content by up to 53 %, and completely inhibited the differentiation of fibroblasts into active myofibroblasts at doses of 150 mg/kg.
After Yiqihuoxue treatment, dermal thickening was notably improved (P = 0.024).
The papillary dermal thickening was pronounced with papillomatosis.
Similar(33)
The histological features of dermal and epidermal thickening of RASSF9−/− skin could also be observed with Masson's trichrome staining, which stained collagen blue for better contrast of collagen-rich dermis with collagen-free epidermis (Figure S3).
This is associated with epidermal thickening, dermal neovascularization and fibrosis, and infiltration by eosinophils, macrophages and dendritic cells.
Treatment with the anti-inflammatory drug dexamethasone (DXM) markedly reduced epidermal thickening and dermal cellularity.
During early organogenesis of the HF, the hair germ layer becomes visible as an epidermal thickening and the dermal fibroblasts immediately below the thickened germ layer start to change their orientation.
The secondary criteria of selection were: pronounced dermal edema, exocytosis, regular or irregular acanthosis, papillomatosis, swollen dermal papillae, dilated blood vessels in dermal papillae, epidermal atrophy, thickened basal membrane area and dilated hyperkeratotic infundibula.
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