Exact(2)
1, 2 Loss of bone and soft tissue volume, redistribution of fat, and decreased dermal elasticity and thickness contribute to the formation of wrinkles and folds, which commonly characterize the aging process.
Skin aging involves increased susceptibility to injury and infection, reduced wound healing, loss of dermal elasticity, poor epidermal barrier maintenance, wrinkling, hair loss, and increased cancer risk (McCullough & Kelly, 2006).
Similar(6)
Tsukahara and colleagues (2001) demonstrated that ovariectomized rats exposed to UVB radiation display an increased formation of deep wrinkles, decreased skin elasticity and marked and advanced curling of dermal elastic fibers compared to rats with normal estrogen levels.
This led the authors to suggest that ovariectomy causes an increase in elastase mediated degradation of dermal elastic fibers with a subsequent reduction in skin elasticity, thus explaining the skin changes seen in post-menopausal women.
The microfibril components associated with elastin help regulate the formation, assembly, and stabilization of elastic fibers, and they are also critical for dermal integrity and elasticity.
Improvements in the study were explained by direct effects on the associated lymphedema [ 17] in combination with enhanced skin elasticity, dermal revitalization, and smoothness by disruption of fat components and fibrous septae [ 18].
Macroscopically it is recognized by fine wrinkles, loss of elasticity, reduced epidermal and dermal thickness, while microscopically epidermal atrophy, decreased mitotic rate of basal keratinocytes, decreased proliferative capacity and cellular senescence, atrophy of the dermal extracellular matrix and change of the physiological properties of the connective tissue are typical characteristics.
In suitable patients, hormone replacement therapy has been repeatedly demonstrated to rehydrate, increase collagen content, elasticity and dermal thickness.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com