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In these studies, GzmB deficiency protected against a loss in dermal collagen density and skin thinning, and accelerated wound closure.
Loss of dermal collagen density and organization is a hallmark of chronically aged skin and contributes to macroscopic changes in skin appearance (Fisher et al., 1997).
High resolution ultrasound skin imaging (DermaLab SkinLab USB) was used to assess the effect of the liquid food supplement, Pure Gold Collagen, on dermal collagen density in healthy volunteers.
GzmB deficiency significantly protected against the formation of wrinkles and the loss of dermal collagen density, which was related to the cleavage of decorin, an abundant proteoglycan involved in collagen fibrillogenesis and integrity.
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In vivo, OCT was administered to BLM-induced scleroderma model and outcomes were determined by dermal thickness, collagen density and POSTN expression.
Globally, the dermal thickness, its collagen density, and content were reported to be possibly maintained in HRT receivers compared to age-matched untreated women [ 2, 22].
Autologuous fibroblasts increase thickness and density of dermal collagen.
Another study, which observed an increase in the echogenicity of the subepidermal low-echogenic band by ultrasound analysis after HA-based mesotherapy every week for 4 weeks on the dorsum of the hands, also suggested these changes may be related to an increased density of dermal collagen fibres by fibroblast activation resulting from treatment [ 13].
4 Histologically Ditre and colleagues showed that AHAs increase collagen density and mucopolysacccharides, causing increase in dermal thickening.
Shuster and co-workers reported a direct relationship between skin collagen and dermal thickness in a study correlating age and sex with skin thickness and collagen density [ 16].
Between the cuticle and dermal collagen there are granular deposits which might be immune complexes involving the collagenous component of cuticle.
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