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We also evaluated the therapeutic advantage of dermal administration of CysA in rat model.
We also evaluated the therapeutic advantage of dermal administration of Cyclosporin A in rat model.
The aim of the present study was to design and optimize a nanoemulsion for dermal administration of mixtures of natural or synthetic pentacyclic triterpenes with recognized anti-inflammatory activity.
Rats of all groups that received a dermal administration of each carbamate did not show differences (P > 0.05) with the control groups.
The number of rats who died or were euthanized due to clinical signs of severe toxicity due to the oral or dermal administration of the carbamates in this study is shown in Table 2.
The present work was designed to ascertain the antibacterial activity and safety levels for the dermal administration of ethyl acetate extract of C. Bauchiense in the treatment of dermal bacterial infections.
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In rats, after oral and dermal administrations of 100 mg BP-3/kg body weight (Kadry et al. 1995; Okereke et al. 1993, 1994, 1995), the parent compound and three oxidative metabolites (2,4-dihydroxylbenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, and 2,3,4-trihydroxybenzophenone) were detected in plasma, tissues, and urine.
In Aotus monkeys and pigs, intra-dermal administration of DNA vaccine by needle and syringe is reported to be more effective at inducing an immune response than intra-muscular administration by needle and syringe [ 9, 10].
Decreased exposure of the ocular tissues to the active drug may account for the reduced incidences of adverse events observed with dermal administration.
Nanomedicines may allow for novel routes of delivery including oral, pulmonary, and dermal administration, which requires high bioavailability through the biological barriers.
However, surfactants edge activated transfersomes frequently lead to cutaneous irritation, skin lipid loss and other side effects after dermal administration.
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