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Efficient intracellular and dermal accumulation of vitamin E from ethosomes was demonstrated.
Increased dermal accumulation of strongly red birefringent collagen fibers was noted in Nab2−/− mice compared to wildtype littermates (Fig. 5A, panels e,f).
The TGFβ dysregulation, fibrosis and dermal accumulation of microfibril aggregates observed in SSS and the acromelic dysplasias would then be a secondary response to an altered signalling program initiated by changes in the surface interactions with microfibrils.
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Ulcers had thick adherent serocellular crusts and were delineated by small dermal accumulations of heterophils and fewer macrophages.
Consistent with decreased dermal thickening, reduced accumulation of collagen upon bleomycin challenge was observed on trichrome-stained skin sections of mice treated with MR16-1.
We therefore suggest imatinib to act as a dose-dependent inducer of chemoattractant substances like, for example, cytokines and growth factors leading to dermal mast cell accumulation.
Protoporphyria (PP) resulting from two rare, inherited diseases of heme biosynthesis leads to dermal phototoxicity by accumulation of the heme precursor protoporphyrin IX.
Engineered skin exposed to SWCNT showed increased epidermal thickness and accumulation and activation of dermal fibroblasts which resulted in increased collagen as well as release of pro-inflammatory cytokines.
Psoriasis is a chronic inflammatory disease of skin and small joints characterized by excessive growth of the epidermal keratinocytes, inflammatory cell accumulation, and excessive dermal angiogenesis.
Concomitantly with the tight skin phenotype at two weeks of age, Tsk2/+ mice demonstrate increased levels of total transforming growth factor beta 1 (TGF-β1) and excessive accumulation of dermal elastic fibers.
Furthermore, in animal models of TGF-ß-dependent fibrosis, rosiglitazone treatment attenuated the development of dermal thickness and collagen accumulation in vivo [21], [32].
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