In case A, methylation of one X chromosome in HER2+ area and methylation of the other X chromosome in HER2− area strongly suggest the existence of two distinct tumours, deriving from two distinct initiating tumour cells.
Several distinct genetic mechanisms lead to acute lymphocytic leukemia (ALL) malignant transformations deriving from distinct lymphoid precursor cells that have been committed to either T-lineage or B-lineage differentiation.
Third, and what seems pivotal in the search for molecular targets in activating BAT thermogenesis, are the demonstrations that these two types of brown adipocytes (classic vs. brite) may derive from distinct precursors and possess distinct molecular signatures.
To suppress their differentiation, stem cells require extracellular signalling cues which derive from a distinct cellular microenvironment called the stem cell niche (Losick et al., 2011).
Similar ATP-dependent Cl− current profiles were recorded in iPSC-RPEs derived from two distinct clonal iPSCs of the same donor (Supplementary Table 1).
Similar ATP-independent Cl− current profiles were recorded in iPSC-RPEs derived from two distinct clonal iPSCs of the same patient donor (Supplementary Table 1).
Using gene expression data derived from these distinct cellular compartments, we demonstrated that Atrx-dependent transcriptional alterations were strongly correlated and anti-correlated with those of developing astrocytes and oligodendrocytes, respectively (Fig. 2f).
The difference between the two processes derives from the distinct behaviour of iron and of mercury when those metals are used as cathodes (negative terminals).
Our study suggests that the A-type granite was derived from a distinct magma source rather than through fractional crystallization of the coeval calc-alkaline magmas.
The majority of these incidents derive from two distinct cases of contamination of unauthorised GM rice lines, LLRICE from the USA and BT63 rice from China.
Nucleotide sequence analysis showed that these clones contained cDNA derived from four distinct genes, which were named RF2-interacting candidate factors (RIF1, RIF2, RIF3 and RIF4; Table 1).
