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The key advantage of MUSE was that it derived the risk of each entity not only by considering its own characteristics but also by incorporating the influence from its neighbors.
We derived the risk equation using a binomial equation and standard HIV modeling techniques [ 50, 51].
For the RS-assay model, we derived the risk distribution and monthly transition probabilities from remission to LR, DR and Death over 10 years within each risk level from retrospective analyses of the NSABP chemotherapy-tamoxifen trials (B-14 and B-20) (Table 2) [ 9, 11].
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Density levels of the toxic substance in the unique environment are developed from models (both simple and sophisticated) in order to derive the risk contours.
If data of the necessary resolution and quality are available, a robust burn yield analysis could be used to derive the risk metrics.
In simplest terms it could be articulated with fitting a distribution of the yield based on the observed (recorded) yields, probabilistic yield sampling from the distribution, and determination of the reduction of the yield (burn) to derive the risk metrics.
For the case-cohort estimates the Prentice weighting scheme was used to derive the risk predictions.
The entire data set (n = 43,561 children) was used to derive the risk prediction score of death.
For external validation, they should describe the populations that are used for the validation, particularly the comparability with the population that was used to derive the risk model.
Consequently, a new dose-response model was developed, based on the outbreak data, and was used with exposure assessment information for eggs and broiler chickens to derive the risk estimates.
Predictors used in deriving the risk score and the outcome of HCC ascertained after follow-up of the entire cohort were collected.
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