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We found that rampant epistasis within and between the two molecules was essential to specific TF-RE recognition and to the evolution of a novel TF-RE complex with unique derived specificity.
Because none of the replacements acted as a switch that impaired binding to some sequences while improving affinity for others, multiple replacements were necessary to achieve the derived specificity and affinity.
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For each questionnaire this was cross tabulated with a qualitative assessment of change derived from the interview data and standard methods used to derive specificity and sensitivity.
All three amino acid replacements in the RH therefore contributed to the derived DNA specificity, and their effects depend on the background into which they are introduced.
Table 2 lists the derived sensitivities, specificities, and predictive values at different cut-off concentrations.
Table 5 lists the derived sensitivities, specificities, and predictive values at different cut-off concentrations (according to NGAL Qs).
Circulating CD8+ T lymphocytes derive their specificity from highly variable but clonally distributed T-cell receptors (TCRs) that inspect class I major histocompatibility complex (MHC) glycoproteins.
We derived sensitivity and specificity for delivery <37 weeks for fetal fibronectin and for abnormal cervical length.
Therefore, it is anticipated that the efficacy of adoptive T cell cancer immunotherapy can be dramatically improved by utilizing "young" T cells with targeted antigen specificity derived from umbilical cord blood, instead of current practice using autologous senescent T cells derived usually from aged cancer patients.
Based on those four results other two statistical measures have been derived: Sensitivity and Specificity.
Their greatest advantage is their chromosome specificity derived from the flanking sequences unique to individual chromosomes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com