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These decision trees are mostly empirically derived from validation studies in the field, and by input from the CLASlite user community [27].
The calculation requires an estimate of the probability of detection at the concentration(s) of interest, usually derived from validation or calibration standard data.
These decision trees are mostly empirically derived from validation studies in the field, and by input from the CLASlite user community [ 27].
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The confidence grouping derived from cross validation performance compared to random models performed well overall in identifying models that are outperformed by random in <5% of cases in EHR validation (Table 3).
Further, as exploration moves beyond LEO and measured data become sparse, the uncertainty estimates derived from these validation cases will no longer be applicable.
In the combination step, the posterior distributions of model parameters and discrepancy corresponding to different priors are combined into a single distribution based on the probabilistic weights derived from the validation step.
Model 5 was derived from a validation study of the Portuguese version of the SWBQ (Gouveia et al., 2009) in which the authors found inconsistencies and suggested rewording items 6, 8 and 9 to improve psychometric properties of the questionnaire.
Bayesian statistical testing [36], [37] of these results verified that substrates that were ubiquitylated on the protein microarrays had a high-probability of being true substrates of ubiquitylation in vivo (the null hypothesis was tested H0∶ p = 0.5 against the probability P* = 0.63 derived from our validation data and rejected with evidence ev = 0.89).
The scores presented in this table were derived from the validation study conducted with 152 patients.
Predictions by the five individual models derived from cross validation were combined using simple majority voting.
The accuracies of the mBVs for each breed were derived from the validation animals using two different methods.
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