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Support for this notion is also derived from the finding that fragments of the mAb Guy's 13 expressed in tobacco largely accumulate in the intercellular fluid [ 10].
This premise was derived from the finding that the espG/orf3/tir triple mutant is completely defective at causing a loss in TER much like the eae mutant, despite the presence of EspF and Map in these strains.
Models derived from the finding that TRY and CPC compete with GL1 for binding to GL3 in yeast three hybrid experiments suggest that differential complex formation renders the proposed activator complex inactive [ 14, 29].
Evidence in favor of this hypothesis is derived from the finding that Doxorubicin causes increased ceramide synthesis (although the authors do not refer to previous literature that has already established this finding).
Perhaps the most widely used cellular assay for the functional integrity of the BRCA1 BRCT domain is a transcriptional assay, derived from the finding that the BRCA1 BRCT domain can act as a transcription activation module in both human and yeast cells when tethered to a heterologous DNA binding domain.
LKB1 is thought to be constitutively activated in cells, even under conditions in which AMPK is activated (Alessi et al. 2006), an idea derived from the finding that the LKB1 complex is not stimulated by AMP in vitro and that LKB1 activity is not variable in different cell lines (Woods et al. 2003; Lizcano et al. 2004; Shaw et al. 2004).
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This idea is derived from the findings that tumor regression was observed in immunocompetent hosts while cancer incidence increased in immunocompromised hosts (Salih and Nussler 2001).
This is derived from the findings that a survey of 100 journals showed not only more research articles originating from both Asian countries and worldwide, but also a higher proportion of Asian articles relative to the world total than in the SCI Infectious Disease Category.
The importance of this question derives from the finding that Aqp4 deletion is associated with an increased severity of epileptic seizures (Binder et al. 2006).
The confirmation that such mechanism strictly depends on p53, either WT or transcription activity deficient, derives from the finding that SM13 has no effect on FRO cells, a cell line that does not express p53 (Wolf and Rotter, 1985).
Support for an involvement of PP2A also derives from the finding that its Bα (PR55α) subunit is required to downregulate the levels of P-Ser552 and P-Ser675 C-terminal phosphoforms of β -CATENIN in colon cancer cells (Zhang et al, 2009).
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