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Data on countries' public and private health research expenditures combined were derived from publications by Chakma et al 12 and Young et al, 13 14 and were available from 2007 to 2012 for Australia, Canada, China, Europe, India, Japan, South Korea and the USA.
To address the question of how much earlier hypotheses for compound target interactions can be formulated based on information from patents compared to using evidence derived from publications in scientific journals, a reference list of compound target interactions was compiled.
As far as information derived from publications in scientific journals is concerned, there are now a number of well established databases in the public domain (e.g. ChEMBL [1]) that have widespread use when looking at compound target interactions.
The specific question addressed here is how much earlier hypotheses for compound target interactions can be formulated based on information from patents compared to using evidence derived from publications in scientific journals.
Figures 1 and 2 summarise the findings in regards to the question of how much earlier hypotheses for the 130 compound target interactions in the reference set can be formulated based on information from patents compared to using evidence derived from publications in scientific journals.
For the majority (85%) of rare disorders presented in Table 2, data was derived from publications.
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Specific PCR primer pairs for human CYP3A4 and CYP3A5 gene were derived from publication.
Two evaluations of the urine CCA test for S. mansoni were performed on data derived from two publications (total population 569, year of publication 1995).
A total of three evaluations of the serum CAA test for S. haematobium were performed on data derived from three publications (total population 990, years of publication 1995 to 1999).
A total of five evaluations of the serum CAA test for S. mansoni were performed on data derived from four publications (total population 1583, years of publication 1995 to 1998).
The model was validated for Chlorella sorokiniana with 52 experiments derived from eight publications and for Chlamydomonas reinhardtii with 32 experiments derived from seven publications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com