Data on countries' public and private health research expenditures combined were derived from publications by Chakma et al 12 and Young et al, 13 14 and were available from 2007 to 2012 for Australia, Canada, China, Europe, India, Japan, South Korea and the USA.
The specific question addressed here is how much earlier hypotheses for compound target interactions can be formulated based on information from patents compared to using evidence derived from publications in scientific journals.
To address the question of how much earlier hypotheses for compound target interactions can be formulated based on information from patents compared to using evidence derived from publications in scientific journals, a reference list of compound target interactions was compiled.
As far as information derived from publications in scientific journals is concerned, there are now a number of well established databases in the public domain (e.g. ChEMBL [1]) that have widespread use when looking at compound target interactions.
Figures 1 and 2 summarise the findings in regards to the question of how much earlier hypotheses for the 130 compound target interactions in the reference set can be formulated based on information from patents compared to using evidence derived from publications in scientific journals.
Downloadable data tables, for more convenient offline data analysis, are derived from publications and are current as of the time of publication.
Data pertaining to vaccine potential of the antigens was derived from publications describing global analyses of preselected antigens for their potential to induce an immunoprotective response [ 25, 95- 97].
The strengths of the modelling reported in this work include the construct of model parameter values, which were mostly derived from publications concerning women with BRCA1 or BRCA2 mutations.
