MicroRNAs (miRNAs) are small regulatory RNAs, ~22 nucleotides (nt) in length that are typically derived from a single arm of imperfect, ~80-nt long RNA hairpins located within polymerase II (pol II -derived transcrII -deriveded transcriptsreferreds (pri-miRNAs) (Fig. 1).
The McGill coat of arms is derived from an armorial device assumed during his lifetime by the founder of the University, James McGill.
The coat of arms is derived from an Aztec legend that their gods told them to build a city where they spot an eagle on a nopal eating a serpent, which is now Mexico City.
The coverage of each miRNA arm derived from a known miRNA locus (sense or antisense) was counted for each tissue.
Hydrogels prepared from poly ethylene glycol) (PEG) are widely applied in tissue engineering, especially those derived from a combination of functional multi-arm star PEG and linear crosslinker, with an expectation to form a structurally ideal network.
The primary measure is arm symptoms, derived from a breast cancer specific questionnaire (BR23).
The 5′ homology arm was derived from a bacterial artificial chromosome (RP11 889I17) encompassing the human insulin locus using ET cloning as described previously [ 7].
Furthermore, our previous studies indicate that the extra DTCs present in lin-35 ; fzr-1 gonads are derived from a single precursor DTC in each arm and are not due to mis-specification of the DTC fate by other cell types (Fay et al. 2002).
The essential criteria [ 25] were used for selecting the miRNA candidates, e.g. sequences of miRNA precursors can fold into a hairpin secondary structure that contains the ~21 nt mature miRNA sequence from one arm and miRNA* derived from the opposite arm, both of which form a duplex with two nucleotide, 3' overhangs.
In contrast, for major tumor-suppressive miRNAs, the mature miRNA is derived from the arm that harbors the more toxic seed.
We also included some miRNAs derived from the 3' arm of miRNA stem loop, such as miR-19 and miR-29.
