We also excluded preterm births (< 37 weeks gestation) (n = 568) and women who were less than 18 years old (n = 183), as the BMI classification used was derived for ages 18 and older.
For this study, we excluded 491 women who were either missing information on BMI or GWG (the principal determinants of interest), missing information on gestational age (needed for outcome variables) or were less than 18 years old because the BMI classification we used was derived for ages 18 and older.
The proportions of unaffected first-degree relatives (FDRs) testing positive or negative was derived for each age cohort.
Separate regression coefficients were derived for each age group and end point [half-life, clearance, AUC, volume of distribution (Vd)], with the regression coefficient representing the age group:young adult ratio of parameter values.
Since the cut-off of ≥ 50 cells/μl was previously derived for children age ≥ 60 days, [ 16] we first confirmed its validity among neonates and young infants by constructing a receiver operating characteristic curve (ROC) for total CSF leukocyte count versus CSF culture positivity.
The possible CODs determined by the InterVA-4 model were derived for all ages.
We apply a least squares Monte Carlo approach previously derived for fitting age-depth models to an analogous system of U/Th data vs depth in speleothem records (e.g. Drysdale et al., 2004, 2005).
In addition, as OA may be recorded as joint pain in the older population, the prevalence of OA or joint pain was derived for the population aged 45 years and over.
Overall counts were derived for three broad age groups (16 35, 36 64 and 16 64 years), and for each of these, by sex and ethnicity.
We analysed 50 replicates of each scheme using Physher with a strict, local, and discrete clock and the confidence intervals of the root were derived for the root age using the methods described previously.
