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We derived cost variables from institutional statistics and from values quoted in the literature.
A profit efficiency model needs both input costs and output prices as discussed by Färe et al. [2, 3], while Färe and Grosskopf [4] derived cost and profit functions from directional technology distance function.
Unfortunately, what is yet missing in approach is a clear mathematical formalization of underlying mathematical problems and a formalized description to apply their derived cost metrics to an IT security scenario.
Combining the prevalence estimates with the derived cost estimates allowed us to model the overall health care burden of RxO abuse in each EU5 country.
We investigated the error-minimization properties of putative primordial codes that consisted of 16 supercodons, with the third base being completely redundant, using a previously derived cost function and the error minimization percentage as the measure of a code's robustness to mistranslation.
Subsequently, the economic burden of influenza was extrapolated for the whole of Germany by applying the derived cost per episode to independently published estimates of influenza-associated excess physician consultations per season thereby considering influenza seasons of the last 10 years.
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Due to economies of scale, for instance, or differences in technologies operating at hubs, the derived costs vary at these nodal points.
Therefore, for AMI, we derived costs from Australian Refined Diagnosis Related Group (AR-DRG) and health service utilisation data.
Others derived costs from surveys of private practitioners [ 6, 17, 20] and here the validity of the cost estimates was influenced by the size of the study.
These derived costs fit nicely to the official reference costs of €1,730 for an ICU day in The Netherlands, which is based on a global top-down approach.
Subsequently, during recent years, there has been an increased focus on programs for preventing or reducing work related mental distress in order to improve the psychosocial work environment and lower the derived costs [ 1, 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com