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Understanding the dynamics of the cellular uptake of nanoparticles in human derived (cancer) cells is crucial to the rational design of functional nanoprobes that can be used for the targeting and delivery of drugs.
Unfortunately, we also found constant and reproducible development of NPC derived cancer mainly sustained by the insulin secretion.
To date dissemination and metastatic outgrowth has mainly been attributed to clonally derived cancer cells.
It has recently been linked with enhanced chemoresistance and tumorigenecity of gastric cancer derived cancer stem-like cells [ 23].
Ex vivo experiments revealed that loss-of Evi in different glioblastoma cell lines and glioblastoma derived cancer stem-like cultures affected cell proliferation, migration and apoptotic cell death.
Interestingly, in the present study, both human breast carcinoma derived cancer cells showed increased cytotoxicity with Apo-bLf compared with Fe-bLf particularly after 48 h.
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In addition, tumors derived from CYT387 and paclitaxel-derived cancer cells had a lower expression of CA125.
Herein, we report the development of a drug screen to identify small molecules capable of selectively targeting chemoresistant patient-derived cancer cells.
Moreover, Soeda et al. reported that intratumoral hypoxia promoted the self-renewal capacity of CD133-positive human glioma-derived cancer stem cells.
In order to analyse the functional role of Evi in glioma cells, we silenced Evi in glioblastoma cell lines and glioblastoma-derived cancer stem-like cells.
Here, we describe a strategy to identify compounds that selectively target patient-derived cancer stem cell-like tumour-initiating cells (TICs) while sparing normal paediatric stem cells (skin-derived precursors, SKPs) and characterize two therapeutic candidates.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com