We also compared our computationally derived localization assignments with assignments made using other computational methods with images from YGFP (Chen et al. 2007; Huh et al. 2009).
We gained general insights on the problem solution and derived simple assignment rules that lead to the global optimum by exploiting the dual problem formulation.
However, the automatically derived occlusion assignments may still be manually inspected and overruled, and an annotating user may sort occlusions by machine-given confidence values.
We benchmarked our computationally derived localization assignments for one of our wild-type screens, WT1 (Chong et al. 2015), to visually assigned localization annotations from YGFP (Huh et al. 2003) and found 94% agreement among the set of 1097 proteins assigned to a single location by both methods (Chong et al. 2015).
To identify the organisms from which metasecretome clones were derived, taxonomic assignments were designated for the predicted proteins of each insert, based on the best BLASTX hits, where the E-value was less than 1 × 10−5 and query coverage greater than 30%.
The algorithm computes the cost to derive an assignment T n + 1, 1 ′, where t i ′ is guaranteed to be set in opposite direction t i ′ = − T _MAX · sign ( t i ) and computes ΔT = ( T n + 1, 1 − t i ) − ( T n + 1, 1 ′ − t i ′ ).
The COG assignment yields a higher resolution prediction of the molecular function than a gene family assignment derived from PFAM.
The lower and upper bounds are derived through an assignment problem and the composite dispatching rule (ATCS), respectively.
Our experiments show that the derived optimal state assignment results in less power, area, and delay in FSM MCNC benchmarks.
The results show that the time delay derived from flow assignment carried out by this approach is, in most cases, better than those determined using conventional routing heuristics.
The estimated propensity score was the predicted probability of treatment assignment derived from the fitted logistic regression model.
