Therefore, an empiric formula was derived (and subsequently supported by pharmacokinetic modeling); if at least two of the following three characteristics are present, the apixaban dose should be lowered to 2.5 mg bid: age ≥80 years, body weight ≤60 kg, and serum creatinine ≥1.5 mg/dL (or 133 μmol/L).
This concept is both derived from and supported by observations of the traces of eddies on a free surface, and also by other available observations of turbulent flows.
This conclusion is derived from and supported by our and other's observations.
Plant diversity effects on biota are not only due to the presence of key plant functional groups or plant productivity highlighting the importance of diverse and high-quality plant derived resources, and supporting the validity of the singular hypothesis for soil biota.
The governing thermoelastic stability equations of FG truncated conical shells under thermal loadings within the FSDT using Donnell shell theory have been derived and for freely supported boundary conditions are reduced to a set of linear algebraic equations using the Galerkin's method.
For each patch, a feature vector of contact frequencies and SASA values (per amino acid) was derived, and a support vector machine (SVM) [ 234] was used to segregate interacting and non-interacting residues.
Formula are derived both for uniform and supported catalysts.
Changes of molecular conformation conjectured from peculiar charge state distribution in the electrospray mass spectra were confirmed by collision cross section values derived from ion mobilograms and supported by theoretical calculations.
With respect to the sensed data format, Open GIS Sensor Modelling Language [22] is an established standard that caters for simple, aggregated and derived data concepts and supports multiple encodings (text, XML) as well.
In essence, the three metabolite data sets showed consistency among the data derived from the independent gradients and supported, visually (Figure 2) and statistically (see above; Figure S1), the separation of compartmental-enriched fractions.
