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In this work we show that molecular data can be a useful tool to identify an unknown life cycle stage by tying together different life history stages with the same haplotype and from it derive a hypothesis about the life history of the species.
We subsequently modeled the 3D structure of mtRF1a and mtRF1 bound to the ribosome, highlighting the structural implications of these differences to derive a hypothesis for the function of mtRF1.
This systems analysis enabled us to derive a hypothesis in which hormone signals are proposed to enhance the nitrate response, providing a potential mechanistic explanation for the link between nitrate signaling and the control of plant development.
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The isolated Y-specific and Y-enriched sequences were used to assess the presence of sequence conservation within several Tephritidae species and derive an hypothesis regarding the evolution of the sex chromosomes in this family.
The identified clusters can then form the basis for deriving a hypothesis for the development of a predictive model for new data of the same type.
We derived a hypothesis that household contacts of active tuberculosis patients with latent tuberculosis infection would present with mixed Th1/Th2 cytokine profiles, dominated by high concentrations of Th1 cytokines (due to recent exposure), but accompanied by Th2 and regulatory cytokine production as a result of the on-going immune modulating effects of M.tb infection.
Therefore, from this model, we derived a hypothesis stating that increases in GNI and PEHGDP, which are earmarks of income, as well as increases in FMTS and ISF, will lead to a corresponding increase in the SPBC (70) in all 32 countries.
5 Therefore, we are able to derive a second hypothesis: Hypothesis 2 Since PSPs and CGPs partly provide the same services and referrals from the public to the private sector are uncommon, the density of PSPs should be negatively associated with the density of CGPs.
As supertree methods have been criticized for being biased towards historical trends, we preferred those studies that explicitly set out to derive a phylogenetic hypothesis and so exclude purely (and typically older) descriptive taxonomic works.
Even with the availability of abundant high-throughput data, such limitations still exist mainly due to the lack of appropriate systematic frameworks to analyse and derive a valid hypothesis from them.
In keeping with the epistemological approach of IPA we did not derive a priori hypotheses and instead embraced the aim of finding a window in participants' phenomenological sense-making in relation to diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com