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Majorly, 2,5- and 2,6-disubstituted benzimidazole derivatives shown to induce significant antiTB potential.
Most of these synthetic derivatives shown important cytotoxic actions against individual carcinoma cell line collections, but weak actions against SF, which is as anticipated.
Starting from a series of arylazoenamine derivatives, shown to be selectively and potently active against the bovine viral diarrhea virus (BVDV), we developed a hierarchical combined experimental/molecular modeling strategy to explore the drug leads for the BVDV RNA-dependent RNA polymerase.
Starting from a series of our new 2-phenylbenzimidazole derivatives, shown to be selectively and potently active against the bovine viral diarrhea virus (BVDV), we developed a hierarchical combined experimental/molecular modeling strategy to explore the drug leads for the BVDV RNA-dependent RNA-polymerase.
It should be noted that the total folate content in embryos was lower than the sum of the three folate derivatives shown in the data.
Compared to the GIXD patterns of 6,6′ -BT and 6,6′ -BZ, the GIXD patterns of the 5,5′- substituted derivatives shown in images c and d in Figure 3 reveal an absence of lamellar ordering in the solid state.
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The 4-hydroxy derivatives showed excellent potency and selectivity.
The majority of the NX derivatives showed increased anti-T.
Certain sinapyl alcohol derivatives showed significant cytotoxic activities.
The fluoroethyl-substituted thiophene derivatives showed excellent binding affinities.
Most of the synthesized derivatives showed effective anti-HBV activity.
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