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Compared to the neutral platinum(IV) am(m)ine derivatives in Table 1, the 'p Ka2' value for the am(m)ine protons in the diazido complexes should be dramatically more basic.
An array of artemisinin derivatives in Table 1 with reported anticancer activities against the non-small-cell lung adenocarcinoma A549 cells were selected [16, 17].
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The results of most active derivatives showed in Table 17 (Khan et al. [22]).
The results of most active derivatives showed in Table 11 (Bhat et al. [15]).
The results of most active derivatives showed in Table 6 (Patil et al. [10]).
The results of most active derivatives showed in Table 9 (Jiwane et al. [13]).
The results of most active derivatives showed in Table 3 (Swapna et al. [8]).
The results of most active derivatives showed in Table 14 (Nastas et al. [20]).
The results of most active derivatives showed in Table 12 (Jawale et al. [16]).
The Cambridge Structural Database (version 5.35) [43] and recent literature contain the 53 unique crystal structures of barbituric acid and its 5-substituted derivatives listed in Table 1.
The chemical structures of 11, 13 and all other aryl derivatives discussed in Table 1 may be compared with the previously reported bisaryloxime ethers, potent inhibitors of TTR [39].
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