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In continuation to our interests in the synthesis of pyrazine compounds [21 24] and the enormous applications of pyrazine derivatives in a number of fields prompted us to synthesize new extended iminobenzoates with pyrazine moieties at the terminal positions.
However, additional family members are now known to mediate the cellular uptake of amino acids and their derivatives in a number of tissues [20], [21].
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We found that MG132 routinely used in tissue culture studies as well as its derivative BZ used in a number of clinical trials allow the partial rescue of CMG2 protein in patient cells.
Subsequently, we planned to synthesize 7-arylbenzofuran derivatives which are present in a number of natural products.[ 19] Note that the synthesis of 7-arylbenzofuran from simple precursors remained problematic up to date (Scheme 3).
In a preliminary study, we have investigated whether IFP can release free fatty acids and their hydroxylated derivatives in a limited number of tissues derived from patients with end-stage OA.
Traders and clients base prices for OTC derivatives on a number of 'Greeks' – parameters indicating levels of volatility and other derivative characteristics of the product.
Their model – which is derived from the structure of 14 Å tobermorite – has been used in a number of derivative works (e.g. Ji et al., 2012 ▶) and the paper is already well cited.
Such derivatives can be exploited with good results in a number of biomedical areas, including enhancement of nucleic acid transfection in gene therapy, as well as many other applications aiming to maximize drug delivery and aiding tissue engineering.
The obtained optically active amino acid derivatives can undergo a number of important transformations.
This deal appears less complex — no derivatives involved —but while it has been considered in a number of other states, it has never won legislative approval.
Nevertheless, in a number of foods, in addition to polyphenols, simple phenolic acid antioxidants may occur, especially derivatives of 4-hydroxybenzoic acid and 4-hydroxycinnamic acid [ 19- 21].
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