To reduce the computational cost, these derivatives are estimated by using the first order derivatives available from the previous design points.
In any case, the activity of 16 f and 17 f is equal to that of both the conformationally biased THIQs and the steroidal derivatives from which the nonsteroidal design was conceived.
A new class of 1,2,3-triazol derivatives derived from nimesulide was designed as potential inhibitors of PDE4B.
Herein, we report the design, synthesis, and pharmacological properties of a series of substituted benzylidene acetone oxime ether derivatives from the corresponding oxime derivatives.
They had to get the derivatives from the banks and Wall Street firms.
So the tile-based design may be derivative — from a design point of view — but it works to simplify future development work.
In this study, 35 drug-like hit compounds were selected from the designed 55 tyrosine derivatives based on their better binding affinity (–C-Docker energy) compared to the standard celecoxib (Table 4).
Novel tetrahydrodiazabenzazulene derivatives, designed from the lead compound 1 discovered by screening of our in-house chemical library, were prepared and found to be potent neuropeptide Y-Y5 (NPY-Y5) receptor antagonists.
One was treated with an artemisinin derivative from the start.
A series of dipeptide derivatives from dehydroabietic acid were designed and synthesized as novel antitumor agents.
