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Most of the synthesized derivatives displayed potent activities.
The pharmacological results showed that many of the new derivatives displayed more potent cytotoxicity than alkeran.
Among them, four derivatives displayed excellent to good selectivity indexes against the three different microorganisms.
The pharmacological results showed that many of the derivatives displayed more potent cytotoxicity than sulforaphane (SFN).
On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi.
Additionally, together with selected structure based analogues, both derivatives displayed significant in vivo anti-inflammatory properties.
Some of the derivatives displayed promising curative effect and protective activity against TMV.
Additionally these derivatives displayed superior GI safety profile (low severity index) with respect to the positive control, Indomethacin.
Moreover, these derivatives displayed good antioxidant, Aβ interaction, blood-brain barrier penetration (PAMPA-BBB+) and ADMET properties (in silico).
Similar(2)
Generally 7-hydroxy derivatives display higher NR2B receptor affinities than the corresponding 7-benzyloxy compounds.
Optimized derivatives display high selectivity over IP, FP, and other EP receptor panels.
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