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The ribose derivatives (compound 9 and 10) exhibited modest inhibitory activity.
Of these derivatives, compound 3a showed good Y5 binding affinity with favorable pharmacokinetic properties.
Of these derivatives, compound 20d showed the strongest inhibition of VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC).
Among the synthesized derivatives, compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug.
Among the series of phthalimide derivatives, compound IIh exhibited potent inhibitory activity, with an IC50 value of 8.7 µg/mL.
Among these benzofuran derivatives, compound 16 exhibited the highest BChE inhibition with an IC50 value of 30.3 μM.
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It has been sinking under a $3 billion debt burden for several years, and the hundreds of millions of dollars in fees it owed J. P. Morgan on the derivatives compounded the problem.
A series of new N-substituted isatin derivatives (compounds 2-12) wasynthesizeded.
Among the lycoricidine derivatives, compounds L1 and L3 showed relatively higher induction activities on systemic leaves.
A series of 3-carbamate and 29-ester celastrol derivatives (compounds 1 26) were designed and synthesized.
Twenty-four new 1,3-disubstituted urea derivatives (compounds 1 24) were synthesized and reported for the first time.
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