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This rule suggests us to replace the denominator function of the classical second order derivative with a positive function derived systematically in such a way that it captures most of the significant properties of the governing differential equation(s).
By modifying urosolic acid, we designed and synthesized a derivative with a Ki of 283 nM.
The triamine derivative with a guanidine moiety showed more potent antagonistic activity than memantine.
A derivative with a DS of 1.5 was selected for scaffold preparation.
A pyridine derivative with a triphenylene (Tp) unit is the H B acceptor.
Its derivative with a nitro group ortho to sulfur is methylene green, which has excellent lightfastness on acrylics.
A derivative with a 3,4-dimethoxyphenyl residue at position 3 demonstrates low nanomolar binding affinity for GAK and antiviral activity against dengue virus.
The decrease was due in part to the widespread use of artemisinin combination therapies (ACTs), which combine a fast-acting artemisinin derivative with a longer-acting drug.
We synthesized a novel 1,3,5-substituted triethylbenzene derivative with a benzimidazole moiety as a binding and signalling subunit.
We observed that the three PGT128 family antibodies, particularly PGT128, bound avidly to the NIT82B conjugate (Fig. 3a), which carries an Rv3 derivative with a 1-6-extended D3-like arm.
sgRNA oligos were designed using CCTop63 and selected based on CRISPRi design rules29, then subcloned into a pLKO5 derivative with a fluorescent color (RFP657) and the human U6 promoter for driving sgRNA expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com