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To further investigate similarities between those two sGAG we assessed whether the sHA1 derivative exhibits comparable effects on FN conformation as Hep.
A 2% solution of this derivative exhibits unique oscillatory behaviour under steady shear at the transition point between the dilatant and pseudoplastic regimes.
Compared with the unmodified phosphorothioate oligomer, the phosphorothioate derivative exhibits a higher antisense activity as well as reduced cytotoxicity in cells infected with HIV-1.
DMAKO-05, a novel dimethylation of alkannin oxime derivative, exhibits remarkable anticancer activity as well as excellent cellular selectivity and thus has been considered as a promising antineoplastic agent for colorectal carcinoma and melanoma.
Further mechanism studies of the most active compounds 4a-1-R and 4a-1-S indicathatthis this kind of securinine derivative exhibits a different inhibitory mechanism from that of camptothecin, an established Topo I inhibitor.
This derivative exhibits step discontinuities at the multiple of T time intervals (at the time ticks), and thus n = 2 in (2).
Similar(46)
The fs41 60 derivative exhibited the highest β-galactosidase activity (27.0 units), and the BsZ2 exhibited the lowest activity (4.0 units).
Of the position 18 substitutions investigated, the Lys derivative exhibited the greatest degree of anion selectivity.
One newly synthesized derivative exhibited a remarkably strong activity, with a half-maximum inhibitory concentration value (IC50) of 65 pM.
The objective of this study was to design a novel polyethylene glycol (PEG) derivative exhibiting mucus permeating and mucoadhesive properties.
Imaging studies confirmed the general trend of cell permeability and a cholesterol linked derivative exhibited selective localization into intracellular membranes.
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