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Given the complexity of the statistical analyses, large number of possible predictors and the need to account for some missing data in predictor variables, we propose to recruit at least 7000 children in total (two-thirds for algorithm derivation; one-third for validation), in order to maximise the statistical power of the sample).
4 We included all QResearch practices in England and Wales once they had been using their current EMIS system for at least a year (to ensure completeness of recording of morbidity and prescribing data), randomly allocating two thirds of practices to the derivation dataset and one third to the validation dataset.
Annotations were then exported into a text file using the start (onset) and duration of each seizure, considering all available derivations, with one second resolution.
A random selection of 349 (two thirds) of the 540 remaining patients comprised the derivation cohort and 191 patients (one third) comprised the validation cohort.
24 The attendances were randomly assigned to two subgroups, with two-thirds being used for model derivation and one-third for validation.
15 We included all QResearch practices in England once they had been using their current EMIS system for at least a year (to ensure completeness of recording of morbidity and prescribing data), randomly allocating two-thirds of practices to the derivation dataset with one-third to the validation dataset.
In the analytic work for this paper two-thirds of the available cases were randomly identified for model derivation (n = 390,356), one-third were reserved for model re-test validation (n = 195,532).
For the simplicity, we only give the exact derivation of the second one and the third one can be obtained accordingly.
Analyses in the SUGAR study were conducted among two-thirds of the sample (derivation data set; n=653); the other one-third (n=330) were analysed as the validation data set for the final criteria.
The sample will then be sub-divided into algorithm derivation and validation datasets, compromising two-thirds to one-third of the data set, respectively.
— one-sixth.
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