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Here, in order to assess whether the engraftment potential of SC-NES cells is correlated to their anatomical derivation, we challenged NCX-NES cells with an identical experimental paradigm.
As can be seen, u G is a non-decreasing function of M for a fixed L. However, the mathematical derivations are challenging.
As discussed below, the data documenting the lack of chronic formaldehyde-induced nasal histopathology at concentrations of 1 ppm or less challenge the derivation of Chronic Reference Exposure levels (RELs) or other regulatory guidance levels based on reports of nasal lesions (i.e., rhinitis, squamous metaplasia or dysplasia) in occupationally exposed workers.
The derivation of rules is challenging.
For the sensors the challenge is the derivation of real-time measurement requirements in relation to the separate diagnostic requirements and their respective interface with the PCS.
A well-known challenge is the derivation of meaningful values for the distance thresholds T1 and T2.
Along with many scientific challenges, the future derivation of mature gametes from human stem cells for clinical purposes will be accompanied by several ethical and policy issues (75).
The ICU discharge readiness scores developed by Badawi and Breslow have not been compared to other tools, and their proprietary nature may make independent evaluation challenging, but their derivation and evaluation in a large number of patients and ICUs suggests promise.
As r is a ratio, deriving its expected value is challenging, and the original derivation that ignored second-order terms was subsequently shown to lead to substantial biases in some circumstances (England et al. 2006).
However, due to imperfect CSIT, it is emphasized that the capacity prediction is a big challenge during the above derivation.
Such parameters should be better comparators from in vitro and in vivo, with a major outstanding challenge being measurement or derivation of them in in vivo systems.
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