Deregulation of these activities promotes tumorigenesis, cancer cell invasion, and metastasis [ 46].
My laboratory found that increased serum levels of nucleosomes, along with the changes in apoptosis-related deregulation of proteolytic activities, may be linked to breast cancer progression [ 64].
However, the observed changes in apoptosis-related deregulation of proteolytic activities along with the elevated serum levels of nucleosomes and DNA in blood are linked to breast cancer progression.
Deregulation of kinase activities leads to a variety of pathologies ranging from cancer to inflammatory diseases, diabetes, infectious diseases, cardiovascular disorders, and cell growth and survival [ 1, 2, 5– 11].
Pericellular proteolysis is a crucial biological event: membrane-associated proteolytic enzymes are involved in dynamic rearrangements in cell cell and cell matrix interactions and deregulation of these activities underlies different pathologies, including cancer (Freije et al, 2003).
Loss of p53 or deregulation of its activities leads not only to cancer but also to cardiovascular, metabolic diseases, neurodegeneration and to the process of aging, because of the great number of p53-regulated genes which underlie all these different biological events [ 23] (see Table 1).
Deregulation of HDAC activity and resulting histone deacetylation at normally active sites can lead to cancer.
Increasing evidence suggests that these pathways remain active in a subset of cells within adult organs and that deregulation of their activity contributes to the development and progression of certain tumors [8].
Deregulation of PRMT activity has been linked to several pathological states such as cancer and cardiovascular disorders.
Deregulation of proteasomal activity or improper substrate recognition and processing by the ubiquitin‐proteasome machinery may lead to cancer, stroke, chronic inflammation, and neurodegenerative diseases.
