Sentence examples for deregulated interactions from inspiring English sources

Then deregulated interactions between DEGs were identified and used to construct the individual deregulated biological network.

Enhanced platelet activation and deregulated interactions with circulating leukocytes occur in the setting of small vessel vasculitides [ 40] and large vessel vasculitides [ 7], as well as in SSc [ 41], transfusion-related acute lung injury [ 37, 42] and other inflammatory conditions.

The transformation of normal breast epithelial cells to metastatic cancer is the result of multiple epigenetic and genetic changes, leading to deregulated interactions with the microenvironment [2].

When all individual deregulated networks of a disease were constructed, occurrence frequency of each deregulated interaction in the disease could be calculated.

While deregulated interaction between molecular pattern and TLRs may promote chronic inflammation and tissue damage, recognition of commensal bacteria by TLRs plays an important role in maintaining intestinal homeostasis and contributes to the prevention of intestinal injury [4].

PPI networks have recently been introduced to extract subnetworks of interacting proteins or to identify deregulated molecular interactions, evolving from a pathway-based to a protein-network-based approach [18] [21].

This causes the acquisition of molecular features contributing to the etiology or progression of many diseases, including cancer, where deregulated molecular interactions of signaling proteins have been best studied.

Evidence that OPG has profound effects on bone comes from OPG knockout mice, which are osteoporotic due to deregulated RANKL/RANK interaction and increased osteoclast formation [ 27], and also comes from the administration of OPG to laboratory animals and humans, which leads to an increase of bone mass [ 28, 29].

Mucosal damage and deregulated host-microbial interactions have also been shown to contribute to SIRS and post-SCT complications such as acute GvHD [16], [17].

In cancer, HDAC8 is a major 'epigenetic player' that is linked to deregulated expression or interaction with transcription factors critical to tumorigenesis.

As defined above, if an interaction