Sentence examples for deregulated behavior from inspiring English sources

Her main research focus is on epigenetic state switching and transcriptional dynamics/stochasticity also in the context of deregulated behavior such as UV-induced DNA damage repair and age-related diseases.

Moreover, altered expression of ECM molecules also deregulates the behavior of stromal cells and promotes tumor-associated angiogenesis and inflammation, leading to generation of a tumorigenic microenvironment [ 25].

Moreover, altered expression of ECM molecules also deregulates the behavior of stromal cells and promotes tumor-associated angiogenesis and inflammation, leading to the generation of a tumorigenic microenvironment [ 17– 17].

Our results indicate that, following exposure to breast cancer cell-secreted factors, adipose stromal cells initially deposit in the stroma, high amounts of stiff and unfolded Fn with altered topology, which deregulate the behavior of neighboring cells by modifying cell matrix interactions (altered outside-in signaling).

Let us give human intelligence and agency more credit, and the most fundamental virtues of love and liberty will help us find reasonable mechanisms of regulating and deregulating our behaviors with changing times.

We found that repeated neonatal exposure to isoflurane reduced freezing behavior during CFC testing and deregulated hippocampal histone H4K12 acetylation.

In either case, deregulated TBPH initiates synaptic deficits and impaired motor behavior, ultimately causing age-related and progressive neurodegeneration.

When activated in cancer, this module can substantially affect tissue behavior, yet this occurs not in a deregulated, but in a rather coordinated manner, and thus maintaining functionality for the cell, albeit not one that is in the long-term tolerable for the organism.

Given their critical role as modulators of MAPK/ERK and mediators of the crosstalk between ERK and other signaling pathways for maintaining homeostatic control of cellular behavior, the Sprouty proteins are conceivably expected to be deregulated in malignant conditions.

The Tregs can therefore, be used to abridge the self-aggressive behavior of the fully differentiated CD8+ TEM cells resulting from a deregulated CD4 T cell response.

One of the most feared and lethal consequences of deregulated adhesion signaling that can lead to metastatic spread is invasive tumor cell behavior; however, the underlying cellular mechanisms are complex and include cross-regulation of cell-cell adhesion, migration and extracellular matrix (ECM) degradation (Guo and Giancotti, 2004).