Clinically, MODS was considered as a sequential or concomitant occurrence of a significant derangement of function in two or more organ systems of the body, against a background of critical illness.
MODs can be considered as a sequential or concomitant occurrence of a significant derangement of function in two or more organ systems of the body, against a background of a critical illness [ 42].
It plays many different roles in the brain, some concerned with synapses, the interconnections between neurons, so derangements of its function are a plausible source of schizophrenia.
Because of the critical role the mitochondria play in normal human cell physiology, severe mutations that cause dramatic derangements of mitochondrial function can be fatal [ 2].
There was evidence of increased histological damage in steatotic livers compared to lean controls with corresponding greater derangements of liver function in these animals.
Therefore, this study aimed to analyse the effects of ageing on calcium handling in isolated human right atrial myocytes to gain insight into the pathophysiology of prevalent age-associated derangements of atrial function and atrial disease in humans.
The most important aspect in monitoring the critically ill patient is the detection of life-threatening derangements of vital functions.
As a result of derangement of CRABP2 function, and consequent impairment of RARα function, we found evidence that cells develop homozygosis for epigenetically silent genes that are either RA-receptors (RARβ2) or RA-responsive genes involved in both RA metabolism and morphogenesis (CRBP1 and CYP26A1).
The pattern of derangement of hepatic function, however, was similar in the two groups.
Sometimes these viral invaders turn cells into incubators for more virus particles, which then propagate from cell to cell, causing a variety of symptoms and, ultimately, derangement of normal function within infected cells.
This severe liver I/R model demonstrates derangement of hepatic function, biochemistry, haemodynamic and ultrastructure.
