Indeed, complete functional integration of transplanted cells may become the major hurdle for those tissues where complex intercellular interactions and communication are required for optimal function, reiterating the importance of in depth knowledge of the host microenvironment.
However, engineering such biomaterials requires an in-depth understanding of the host inflammatory and wound healing response to implanted materials.
It is unlikely that the host response can be avoided and, therefore, designs which incorporate an in-depth understanding of the host immune response together with other requisite criteria will likely meet with improved success and downstream functionality.
An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics.
"He was not as flashy as Ravi Shankar, but he had the ability to play a single note, or a simple passage of notes, and draw out such amazing depth," said John Schaefer, the host of "New Sounds" and "Soundcheck" on WNYC-FM in New York.
It is a measure of the evolutionary depth of host breadth, whereas PD also accounts for the phylogenetic density of host use.
Some of the putative factors related to these different clinical manifestations of sporotrichosis are the fungal inoculum size, the host immune status, the depth of the traumatic inoculation of the fungus, and Sporothrix thermotolerance and virulence [ 31].
The presence of inverted pigeonite in the Apollo 14 samples 14082 and 14083 indicates slow cooling of the host rock at a depth of several kilometers (Papike and Bence 1972).
For example, in the transmission geometry (the object sits on the plane z = z′ between r s = 0 and r d) of diffuse optical imaging, the integral ∫ G0(r d; ρ′, z′) G0(ρ′, z′;0) d ρ′ in Eq. (3) equals approximately fG0(r d,0) where the scaling factor f depends on the optical property and the geometry of the host medium and the depth of the object z′.
The temporal changes in gene transcription during the first hours of intraluminal injection of L. plantarum as described in this manuscript provides an in-depth overview of the cellular host response to intraluminal non-pathogenic microbes.
