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"Some don't understand the depth of conservation.
Interestingly, comparison of the exonic and intronic subset by ANOVA analysis (Table 3 and illustrated in Figure 3) shows that their SNP densities are not significantly different at any depth of conservation.
Together, these findings indicate that the classification of miRNAs as highly, moderately and lowly conserved miRNAs on the basis of available ESTs alone may not reflect the true depth of conservation.
> -wrap-foot> Here, we should note that these classifications should be considered as a minimal depth of conservation, as orthologs might be found by scanning additional species, different evolutionary groups, or finished genomes as they become available.
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For all depths of conservation the model gives us strong evidence supporting our hypothesis.
For all shown depths of conservation a striking growth of the number of putative autoregulatory binding sites is observed in the bin located directly upstream of the TSSes.
Their number, mutual organization, and depth of phylogenetic conservation vary.
Target sites can furthermore be evaluated based on seed type and context contribution as well as depth of evolutionary conservation [ 6, 14].
The depth and breadth of conservation of these sequences is indicative of a fundamental regulatory role.
For each phylogenetically confirmed cluster of orthologous genes in which at least Caenorhabditis elegans, Drosophila melanogaster, Anopheles gambiae, Saccharomyces cerevisiae are altogether present; and human and mouse are both absent; we sought in depth for traces of conservation in mouse and human genomes, and more generally in mammalian and vertebrates genomes using blast.
Additional taxon sampling in the family Selenastraceae will be necessary to determine the phylogenetic depth of this genomic conservation.
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