Sentence examples similar to depth of binding from inspiring English sources

Strikingly the non-conserved Tyr125 side chain has flipped out to accommodate the methoxy group of the isoxazolo moiety and this may account for the improved inhibition of compound 1 over acetazolamide in AfChiA1 by facilitating tight interactions of the neighbouring pyrimidine moiety within the depths of binding pocket.

We therefore categorized TFBRs based on how many mouse species they occurred in and discovered that, within one mammalian genus, there are steadily increasing intensities for each TF with increasing depth of TF binding conservation.

Thus, novel pocket descriptors allowing an in-depth characterization of binding sites are highly desired.

The design of the array also allowed for further in-depth analysis of binding to both unidirectional and bidirectional promoters.

Several interesting trends become apparent upon a more in-depth comparison of binding trends for 2 and 3.

This CID forms a "wall" alongside the TIM barrel which increases the depth of the substrate-binding cleft, facilitating binding to long-chain substrates, and favoring the processive degradation of chitin (Li and Greene 2010; Zees et al. 2009; Vaaje-Kolstad et al. 2013).

Surface volume measurements (Figure 4A, mesh surface) at these residue positions showed the depth of DDX3X-ATP binding cavity to be more compared to other helicases (average Δ vol = 58 Å).

Specifically, as the 6-methyl moiety of the pyrimidine ring engages the depth of the AfChiA1 binding pocket there may be scope for larger substituents in this position to fully occupy this space.

To define the relationship between each factor across the four tissues that were examined, we looked at the pairwise Spearman rank correlations of normalized read depth within a collective list of binding sites.

The tremendous depth of coverage of the binding peptide profiles also permits robust computational analysis.

Moreover, our methodology does not require in-depth details about the number of binding conformations or the number of structural signatures.