Location of tumors, urgency of operation (elective or emergency), depth of tumor invasion, tumor type, tumor grade and lymphovascular permeation were summarized in Table 1.
If necrosis was replaced by depth of tumor or tumor size, only depth of tumor showed an effect (p = 0.016; p = 0.332).
When compared with other parameters such as the depth of tumor invasion, tumor volume was identified as a significant prognostic factor (P < 0.001; relative risk 10.351).
TS and DPD activities showed no clear relationship to any of the following pathological findings: histological type, lymph node metastasis, depth of tumor and tumor size.
All cases were reviewed by pathologists to verify the original histopathological diagnosis, depth of tumor, invasion, tumor differentiation and lymph node metastasis.
Furthermore, STAT1 expression was also found to correlate with the depth of tumor invasion and tumor size.
STAT1 expression inversely correlated with the depth of tumor invasion and tumor size (p=0.047 and p=0.029, respectively, Chi square).
Eradicative degree of surgery, pathologic stage, depth of tumor invasion and tumor location were also identified as independent prognostic factors found significant.
Therefore, an objective system for classifying the depth of invasion of a tumor appears to be necessary in order to improve the results of BSCC treatment.
As a result, the difference in coverage depth of an amplicon between tumor and germline can be indicative of chromosome copy number gains or losses.
